Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ 1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride
Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.
MilliporeSigma™ Calbiochem™ TOPK/PBK Inhibitor, HI-TOPK-032
A cell-permeable, selective, ATP competitive, reversible inhibitor of T-LAK-cell-originated protein kinase (IC50 = 2 μM).
MilliporeSigma™ Calbiochem™ PP2
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC50 = 4, 5, 5, & 100 nM for p56lck, p59fynT, Hck, & Src, respectively).
MilliporeSigma™ Calbiochem™ Apoptosis Activator III, Embelin
The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ β-Secretase Substrate VI, Fluorogenic
A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ∽4.0, k
MilliporeSigma™ Calbiochem™ PKCε Peptide Substrate
Pseudosubstrate region of the ε-isotype of protein kinase C (PKCε
MilliporeSigma™ Calbiochem™ Luciferase Inhibitor II
The Luciferase Inhibitor II, also referenced under CAS 10205-56-8, controls the biological activity of Luciferase.
MilliporeSigma™ Calbiochem™ Phosphatase Inhibitor Cocktail Set IV
A cocktail of three phosphatase inhibitors for the inhibition of both serine/threonine and alkaline phosphatases.
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set III, EDTA-Free
Protease inhibitor cocktail III, EDTA-free for inhibiting aspartic, cysteine, and serine proteases as well as aminopeptidases in mammalian cells and tissues.
MilliporeSigma™ Calbiochem™ (-)-Cytisine
A potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respective
MilliporeSigma™ Calbiochem™ Fatostatin
A cell-permeable diarylthiazole compound that prevents the cellular activation of the SREBP-1/2 precursors to the active nuclear forms by blocking SREBPs-SCAP ER to Golgi translocation.
MilliporeSigma™ Calbiochem™ IRAP Inhibitor, HFI-419
A substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 μM against 25 μM Leu-AMC).
MilliporeSigma™ Calbiochem™ Prokineticin 2 Antagonist, PKRA7
A cell permeable, brain permeant antagonist of polypeptide chemokine prokineticin 2 receptor (IC50 = 5 nM and 8.2 nM for PKR1 and PKR2, respectively).
MilliporeSigma™ Calbiochem™ HIF Inhibitor VII
A cell-permeable benzoxadiazolamine that prevents HIF-2α-HIF-β/ARNT heterodimeration by perturbing HIF-2α Per-ARNT-Sim/PAS-B domain surface β-sheet conformation via a 1:1 stoichiometric binding ( K D = 81nM), while exhibiting no affinity toward HIF-1αPAS-B
MilliporeSigma™ Calbiochem™ InSolution™ Q-VD-OPh, Non-O-methylated
InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).